Then he went home, and the crowd gathered again, so that they could not even eat. And when his family heard it, they went out to seize him, for they were saying, “He is out of his mind.”
Mark 3:20-21 ESV
The crowd gathers around Jesus and this time they can’t even do anything since the crowd’s number is exceedingly great. His popularity makes his family heard about him, but instead of supporting Jesus or approving his action, they actually think that Jesus is out of his mind.